C RtSIO R is a registered trademark and IT’S IME is a trademark of the AstraZeneca group of companies ©2C08 AstraZeneca Pha-msceuticals IP AT rights rese'ved. 2558S2 2/08

While you've been building your life,

plaque may have been

1

building in your arteries.

If you have HIGH CHOLESTEROL, you may be at risk for a progressive disease

called atherosclerosis, the buildup of plaque in your arteries over time.

CRESTOR helps fight plaque buildup.

Atherosclerosis (also called "athero") is something you may

need to be concerned about, especially if you have high

cholesterol. Other health factors, such as family history of

early heart disease, diabetes, or high blood pressure may

also play a role in the progression of atherosclerosis.

Ask your doctor if it's time for CRESTOR. Along with

diet, CRESTOR

lowers your bad cholesterol and

A raises the good. And CRESTOR is approved to

slow the progression of atherosclerosis as part of

a treatment plan to lower cholesterol to goal.

Important Safety Information about CRESTOR:

In adults,

CRESTOR is prescribed along with diet for lowering high

cholesterol. CRESTOR is also prescribed along with diet

to slow the progression of atherosclerosis (the buildup

of plaque in arteries) as part of a treatment plan to lower-

cholesterol to goal. CRESTOR has not been determined

to prevent heart disease, heart attacks, or strokes.

CRESTOR is not right for everyone, including anyone

who has previously had an allergic reaction to CRESTOR,

anyone with liver problems, or women who are nursing,

pregnant, or who may become pregnant. Your doctor

will do blood tests before and during treatment with

CRESTOR to monitor your liver function. Unexplained

muscle pain and weakness could be a sign of a rare

but serious side effect and should be reported to your

doctor right away. The 40-mg dose of CRESTOR is only

for patients who do not reach qoal on 20 mg. Be sure

to tell your doctor if you are taking any medications.

Side effects occur infrequently and include headache,

muscle aches, abdominal pain, weakness, and nausea.

Please read the important product information about

CRESTOR on the adjacent page.

You are encouraged to re p o rt negative side effects o f

prescription drugs to the FDA. Visit www.fda.gov/medwatch

,

o r

call 1-800-FDA-1088.

If you can't afford your m edication

,

AstraZeneca

m ay be able to help.

Get informed about athero. Talk to your doctor about CRESTOR and sign up for your

FREE Take Action Kit and a 30-day free trial offer at CRESTOR.com.

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